Losing Specificity: the Role of the Locus Coeruleus in Age-related Distractibility
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Change in fMRI LC-SN connectivity after two weeks
研究概览
简要总结
A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these declines are still largely unclear. The objective of this proposal is to investigate neural mechanisms of age-related attentional distractibility, focusing on the neural circuit initiated from the locus coeruleus (LC). In the current proposal, the investigators will test the hypothesis that the neural disconnectivity of LC with the salience network (SN) drives failures of ignoring distractors in older adults. The investigators will examine how LC-SN connectivity is associated with selective attention performance, and how improved LC-SN connectivity through a cognitive training program may lead to improved attentional performance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
The participant will not be aware that there are two alternate versions of the attention practice program.
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adult participants
- •No younger than 18 and no older than 75 yrs of age
- •Ability to provide written informed consent
排除标准
- •History of surgery involving metal implants
- •Possible metal fragments in the eyes
- •Pacemaker
- •A history of claustrophobia
- •Weighing over 250 pounds
- •Pregnant or possibility of being pregnant.
- •Severe medical or psychiatric conditions (e.g., blind or deaf, head trauma)
- •Learning disabilities or developmental disabilities
研究组 & 干预措施
Older adult participants
Older adult participants in the study will complete one of two variants of an attention practice program and that will be preceded by, and followed by, an fMRI scan session featuring an attention task
干预措施: Tablet based adaptive criterion task practice program (Behavioral)
Older adult participants
Older adult participants in the study will complete one of two variants of an attention practice program and that will be preceded by, and followed by, an fMRI scan session featuring an attention task
干预措施: Tablet based adaptive multimodal attention practice program (Behavioral)
Younger adult participants
Younger adult participants in the study will complete one fMRI scan session featuring an attention task
结局指标
主要结局
Change in fMRI LC-SN connectivity after two weeks
时间窗: Scan before and after attentional practice (2 weeks between scans)
An fMRI measure of LC-SN connectivity
Change in accuracy on the place-face selective attention task after two weeks
时间窗: Scan before and after attentional practice (2 weeks between scans)
During this task, participants will be presented to with target place stimuli overlaid on nonexpressive faces) and be asked to identify categories of place images ('building' to 'house') selectively as soon as possible while ignoring overlapped faces. The investigators will also include place only images to measure participants' baseline neural activation when there is no distractor. Each image condition will be presented in a mixed event related design that includes 15 blocks for each condition as a function of image type (overlaid vs. place-only). The block order will be counterbalanced and each block will be separated by a 10-s blank screen.
次要结局
未报告次要终点