Brain Structures in Speech Motor Memory Consolidation
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Motor Learning
研究概览
简要总结
These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex following adaptation in order to block retention of learning.
详细描述
Subjects will train using either altered somatosensory feedback or altered auditory feedback (different groups of subjects). Immediately following adaptation, continuous theta burst magnetic stimulation (cTBS) will be applied to either auditory or somatosensory or motor cortex with the goal of blocking consolidation of motor memory. The logic of applying cTBS to both sensory areas is to test the hypothesis that both areas are involved in motor memory consolidation. Subjects leave the laboratory following cTBS and return 24 hours later to assess retention of learning. Learning is assessed as percentage change in speech sounds or movements relative to baseline. Retention is measured on a 0 to 100 scale relative to the end of learning.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •right handed adults
- •no known physical or neurological abnormalities
排除标准
- •patients with:
- •cardiac pacemaker
- •surgical clips or values on the heart
- •metal or metallic fragments in any part of the body
- •pregnancy
- •claustrophobia
- •a personal or family history of epilepsy
- •currently taking antipsychotic drugs
- •currently taking antidepressant drugs
- •currently taking antianxiety drugs
- •history of concussion.
研究组 & 干预措施
Adaptation to Altered Sensory Feedback + cTBS to A1
Adaptation to Altered Sensory Feedback + cTBS to A1
干预措施: cTBS (Other)
Adaptation to Altered Sensory Feedback + cTBS to M1
Adaptation to Altered Sensory Feedback + cTBS to M1
干预措施: Adaptation (Behavioral)
Adaptation to Altered Sensory Feedback + cTBS to S1
Adaptation to Altered Sensory Feedback + cTBS to S1
干预措施: Adaptation (Behavioral)
Adaptation to Altered Sensory Feedback + cTBS to S1
Adaptation to Altered Sensory Feedback + cTBS to S1
干预措施: cTBS (Other)
Adaptation to Altered Sensory Feedback + cTBS to A1
Adaptation to Altered Sensory Feedback + cTBS to A1
干预措施: Adaptation (Behavioral)
Adaptation to Altered Sensory Feedback + cTBS to M1
Adaptation to Altered Sensory Feedback + cTBS to M1
干预措施: cTBS (Other)
Adaptation to Altered Sensory Feedback + Sham cTBS
Adaptation to Altered Sensory Feedback + Sham cTBS
干预措施: Adaptation (Behavioral)
Adaptation to Altered Sensory Feedback + Sham cTBS
Adaptation to Altered Sensory Feedback + Sham cTBS
干预措施: cTBS (Other)
结局指标
主要结局
Motor Learning
时间窗: Performance as measured at the end of learning (30 minute session)
Learning is assessed as percentage change in speech sounds (speech formant frequencies) or movements (movement curvature) relative to baseline.
Retention of Learning
时间窗: 24 hours after learning (re-test lasts 30 minutes)
Retention is measured on a 0 to 100 scale relative to the end of learning.
次要结局
未报告次要终点