NCT00000440已完成2 期
Sertraline and Naltrexone for Alcohol Dependents
National Institute on Alcohol Abuse and Alcoholism (NIAAA)1 个研究点 分布在 1 个国家目标入组 124 人开始时间: 1999年11月3日最近更新:
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 124
- 试验地点
- 1
研究概览
简要总结
This study is a double-blind, placebo-controlled outpatient trial to improve, through the addition of sertraline (Zoloft), the abstinence and relapse rates in alcohol- dependent individuals currently taking naltrexone (Revia).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meets the criteria for alcohol dependence.
- •Abstinent from alcohol for a period of at least 5 days and not greater than 30 days.
- •Able to read English and complete study evaluations.
- •A stable residence and a telephone to ensure that subjects can be located during the study.
排除标准
- •Currently meets criteria for substance abuse or dependence with the exception of nicotine dependence.
- •Current use of disulfiram (Antabuse) or a MAO Inhibitor.
- •Psychotic or otherwise severely psychiatrically disabled (i.e., depressed, suicidal, current mania).
- •Major depression at the time of assessment.
- •Previous treatment with naltrexone (Revia) for alcohol dependence.
- •Significant underlying medical conditions such as cerebral, renal, thyroid, or cardiac disease.
- •Abstinent longer than 30 days prior to admission to program.
- •Hepatocellular disease or elevated bilirubin levels.
- •Females who are pregnant, nursing, or not using a reliable method of birth control.
研究者
研究点 (1)
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