Brown Adipose Tissue Activity Young and Older Individuals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Difference in sympathetic stimulation to BAT between young and older individuals
研究概览
简要总结
In this study the investigators aim to investigate whether the sympathetic stimulation of BAT, as assessed with a 123I-metaiodobenzylguanidine single-photon emission computed tomography computed tomography scan, differs between young and elderly subjects, as an explanation for the diminished metabolic brown adipose tissue activity in the elderly.
The investigators hypothesis is that sympathetic nervous system activity in the elderly is diminished as compared to their younger counterparts as an explanation for the diminished metabolic brown adipose tissue activity in the elderly.
详细描述
The sympathetic nervous system is the primary activator of Brown Adipose Tissue.
Elderly are known to have less metabolically active brown adipose tissue as compared to their younger counterparts.
The reason for this diminished metabolic brown adipose tissue activity is unknown.
However, a lower sympathetic nervous system activation to brown adipose tissue in the elderly might explain a diminished metabolic brown adipose tissue.
Therefore, in this study, both the sympathetic nervous system activation to brown adipose tissue and the metabolic activity will be measured in young and older subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Caucasian origin
- •Subjects should be able and willing to give informed consent
- •18-65 years old
- •BMI range of 19-27 kg/m2
排除标准
- •Renal failure (creatinine>135mmol/l)
- •Daily use of prescription medication
- •Prior participation in a research protocol involving radiation exposure in the last 2 years
结局指标
主要结局
Difference in sympathetic stimulation to BAT between young and older individuals
时间窗: Participants will be followed for a mean duration of 2 weeks (the maximal time period between the two scans) The outcome measurements will be assessed when the last subject has been scanned approximately one year after starting the trial.
次要结局
- Difference in correlation between sympathetic stimulation of BAT as assessed with 123I-MIBG SPECT scans and metabolic BAT activity as assessed with 18F-Fluorodeoxyglucose(FDG)- positron emission tomography(PET)-CT scan in young and older individuals(Participants will be followed for a mean duration of 2 weeks (the maximal time period between the two scans) The outcome measurements will be assessed when the last subject has been scanned approximately one year after starting the trial.)
研究者
F Holleman
MD, PhD
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)