Efficacy of Kabab Chini (Piper cubeba)on microalbuminuria in Diabetic Nephropathy -A Single-Blind Randomised Standard Controlled Trial
试验速览
- 阶段
- 1/2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
研究概览
简要总结
Diabetic kidney disease is a common complication of diabetes mellitus and a major cause of chronic kidney disease and end stage renal disease worldwide. In India a large proportion of patients who progress to end stage renal disease have underlying diabetic kidney disease and chronic kidney disease is frequently seen in people with type 2 diabetes. The growing number of individuals with type 2 diabetes has led to an increase in diabetic kidney disease resulting in significant illness death and healthcare burden. Kabab Chini also known as Piper cubeba is a medicinal plant used in Unani medicine and is reported to have antioxidant anti inflammatory and blood glucose lowering properties. Experimental studies suggest that it may reduce oxidative stress and inflammation which are important factors in kidney damage due to diabetes. However clinical evidence regarding its role in diabetic nephropathy especially in reducing microalbuminuria as an early marker of kidney damage is limited. This study is designed to evaluate the efficacy and safety of Piper cubeba in reducing microalbuminuria in patients with diabetic nephropathy and to explore its potential as an additional therapy along with standard treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 30.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Age between 30 to70 years.
- •Diagnosed with type 2 DM(4 years) with nephropathy.
- •UACR 30-300 mg/g eGFRgreater than 60 HbA1cgreater than6.5% BP 130/80 maintained Those who give written consent.
排除标准
- •Taking potassium-sparing diuretics.
- •Severe anaemia, Hb less than 6 per cent UTI.
- •Severe Cardiovascular and cerebrovascular disease Other primary or secondary renal diseases (e.g., IgA nephropathy, membranous nephropathy, or lupus nephritis).
- •Pregnant or lactating women, women intending to become pregnant, and women not using appropriate contraceptive methods Severe mental disorder Other unstable elements, such as malignancy Drug or Alcohol abuse.
- •Breastfeeding.
- •Drugs that could affect urinary protein or renal function, eg, ARB, SGL-2 inhibitor Ramipril, Nonsteroidal/anti-inflammatory drug, Immunosuppressive drug.
研究者
Nabeela Khatoon
AJMAL KHAN TIBBIYA COLLEGE