Gut Microbiota and Alzheimer's Diseases
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Gut beta-amyloid 42
研究概览
简要总结
The investigator will perform clinical studies to test a hypothesis that participants who have Alzheimer's disease will have different gut/oral microbiota profile as compared to the participants who do not have Alzheimer's disease. The investigators will also check the microbiome of their partners in this study. The investigators plan to perform the studies in 150 participants in Shanghai Tenth's People's Hospital and also in the houses in Shanghai city. Investigators will also measure the beta-amyloid in the feces of the participants. Finally, the investigators will determine cognitive function in these participants.
详细描述
Studies have shown that gut/oral microbiome and beta-amyloid in body may have a significant impact on the behavior and brain pathology consistent with Alzheimer's disease (AD) neuropathogenesis. The objective of this study is to assess whether the gut/oral microbiome and feces beta-amyloid of AD patients are different from those of the participants without AD and their partners. The investigators plan to recruit 150 subjects, including three groups of normal elders, AD patients and the partners of the AD patients. The cognitive function will be assessed and the feces and oral samples will be collected to determine whether there are differences or correlations.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 60 and older
排除标准
- •with other acute gastrointestinal diseases
- •with other severe neuropsychiatric disorders
结局指标
主要结局
Gut beta-amyloid 42
时间窗: Through study completion, an average of 4 year
Gut amyloid-beta 42 will be determined by digital ELISA, traditional ELISA and western blot.
次要结局
- Oral microbiota(Through study completion, an average of 4 year)
- Cognitive function by Mini-mental State Examination (MMSE)(through study completion, an average of 4 year)
- Gut microbiota(Through study completion, an average of 4 year)
研究者
Yuan Shen, MD, PhD
Chief of Psychiatry Department
Shanghai 10th People's Hospital