NCT02063542已完成不适用
Cerebrospinal Fluid Cholinergic Biomarkers and Postoperative Cognitive Change in Aged Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Concentration of acetylcholinesterase in CSF
研究概览
简要总结
Previous study demonstrated that the condition of central cholinergic nerve is important for the postoperative cognitive dysfunction. In present study investigators hypothesized that the acetylcholine concentration in the cerebral spinal fluid is associated to the postoperative cognitive changes in aged patients undergoing osteopathic surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elder than 60 years old
- •Spoke proficient Mandarin Chinese
- •Agree to undergoing spinal plus general anesthesia
- •Selected total knee replacement surgery
排除标准
- •Patients with neurological and/or psychiatric diseases, including AD, stroke and psychosis
- •Have contraindication for spinal anesthesia such as clotting disorder local infection in the puncture site
- •Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
- •Several audition or vision disorder
- •Unwillingness to comply with the protocol or procedures.
结局指标
主要结局
Concentration of acetylcholinesterase in CSF
时间窗: During spinal anesthesia
Concentration of Acetylcholine in CSF
时间窗: During spinal anesthesia
Short-term postoperative cognitive dysfunction rate
时间窗: The day before surgery and 7 days after surgery (or before leave hospital)
Concentration of choline acetyltransferase in CSF
时间窗: During spinal anesthesia
次要结局
- Long-term postoperative cognitive dysfunction rate(Two months after surgery)
研究者
diansan su
Principal Investigator
RenJi Hospital
研究点 (1)
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