The Features Behind the Beneficial Effects of Interval-walking
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Glycemic control
研究概览
简要总结
A single bout of Interval-Walking (IW) exercise is superior to energy-expenditure and time-duration matched Continuous Walking (CW) exercise upon improving glycemic control. The reason IW is superior is unknown.
This study will look into whether it is the larger peak intensity during IW or if it is the alternating exercise pattern that is responsible for the larger improvements seen.
Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:
- One hour of rest (Con)
- One hour of classical interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW3)
- One hour of fast alternating interval walking (repeated cycles of 1 min of fast and 1 min of slow walking; IW1).
After the interventions subjects will undergo a standardized mixed meal tolerance test, with consecutive measurements of blood glucose, insulin and c-peptide.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetes mellitus
- •Body mass index > 18 but < 40 m2/kg
- •Agreement to pause antidiabetic medication from 2 days before to after each trial
排除标准
- •Pregnancy
- •Use of exogenous insulin
- •Contraindication to increased levels of physical activity
- •Evidence of thyroid, liver, lung, heart or kidney disease
研究组 & 干预措施
Control (Con)
No exercise intervention.
干预措施: Control (Behavioral)
Interval Walking - 3 min intervals (IW3)
One hour of classical interval walking exercise (repeated cycles of 3 min of fast and 3 min of slow walking.
干预措施: IW3 (Behavioral)
Interval Walking - 1 min intervals (IW1)
One hour of fast alternating interval walking exercise (repeated cycles of 3 min of fast and 3 min of slow walking
干预措施: IW1 (Behavioral)
结局指标
主要结局
Glycemic control
时间窗: Within the first 4 hours after the interventions
Glycemic control will be measured after each intervention. Subjects will receive a standardized mixed meal tolerance test (MMTT), and blood glucose values will be obtained during the test.
次要结局
- Insulin secretion(Within the first 4 hours after the interventions)
- Insulin sensitivity(Within the first 4 hours after the interventions)
研究者
Anders Rasmussen Rinnov
MD, PhD
Rigshospitalet, Denmark