Cocaine and Sympathetic Nerve Activity in Humans
试验速览
- 阶段
- 1 期
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Skin sympathetic nerve activity
研究概览
简要总结
The purpose of this study is to improve the scientific understanding of the cardiovascular actions of cocaine, in particular the ability of cocaine to increase blood pressure.
详细描述
Cocaine abuse has emerged as a major cause of life-threatening cardiovascular emergencies but our understanding of the underlying mechanisms mediating the adverse effects of cocaine is far from complete. Our previous studies in cocaine-naive human subjects have demonstrated that intranasal cocaine acutely stimulates the human cardiovascular system by a novel central mechanism of action.We are currently investigating a central sympatholytic drug,dexmedetomidine, in reversing the sympathomimetic effects (increase in blood pressure, heart rate and coronary vasoconstriction) of intranasal cocaine.This drug may be a new pharmacologic agent in the treatment of acute cocaine intoxication in humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Cocaine naive healthy volunteers
排除标准
- •Any evidence of cardiopulmonary disease by history or physical examination
- •History of hypertension or 24 hour blood pressure averaging >135/85 mmHg
- •Any history of substance abuse (other than tobacco)
- •Diabetes mellitus or other systemic illness
- •Individuals with a history of pseudocholinesterase deficiency
- •Pregnancy
结局指标
主要结局
Skin sympathetic nerve activity
Skin blood flow
Coronary blood flow
Blood pressure
Heart rate
次要结局
- Sedation status