Assessing the impact of escalating fish oil consumption on n-3 polyunsaturated fatty acid (PUFA) content of transport, storage and functional pools: a randomised controlled trial

MRC Human Nutrition Research (UK)0 个研究点目标入组 210 人开始时间: 2006年4月28日最近更新: 2019年2月11日

试验速览

2012 lipid pool results in: http://www.ncbi.nlm.nih.gov/pubmed/22932281 2. 2014 blood cell and plasma results in: http://www.ncbi.nlm.nih.gov/pubmed/24647395 3. 2014 results on effects of sex and age in https://www.ncbi.nlm.nih.gov/pubmed/24063767 4. 2015 results on use of plasma NEFA as a biomarker in https://www.ncbi.nlm.nih.gov/pubmed/26205910 5. 2015 results on differences in FA distribution between blood cells and plasma in https://www.ncbi.nlm.nih.gov/pubmed/26247960 6. 2017 lipidomics analysis results in https://www.ncbi.nlm.nih.gov/pubmed/28587463

•Men and women, aged 20-80 years with a body mass index (BMI) in the range 18-35 kg/m2 will be recruited to the study.

•1. Known diagnosis of diabetes, cancer, cardiovascular disease or other chronic clinical conditions
•2. Untreated hypertension
•3. Concomitant prescription of anticoagulants, non-steroidal anti-inflammatory drugs (NSAIDS), aspirin, steroids or immunosuppressants
•4. Following a special diet, including vegetarians
•5. Allergies or intolerance to fish
•6. Consumption of oily fish more than once a month
•7. Smokers
•8. History of substance abuse or alcoholism
•9. Pregnant, <1 year post partum or currently planning pregnancy
•10. Recent weight change (>2 kg in past 1 month)
•11. Planning to change dietary habits, increase physical activity, change body weight, move away from the study centre locality or take a lengthy vacation during the time of the study

发起方

MRC Human Nutrition Research (UK)