Long-term Effects of Methadone for Cancer Pain
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Difference between EVA pain score at Day 28 and Day 0
研究概览
简要总结
The methadone is an useful opioid for the cancer pain treatment, mostly used in second or last line during the opioid rotation. The Methadone had an anti-MNDA effect, and clinicians agree that the methadone could have an effect in neuropathic cancer pain. During a previous study the investigators find that the pain was still improving after the week 2, but they had only a small number of patients still included at this stage and they cannot conclude.
The investigators decide to follow up systematically all the patients undergoing a methadone treatment for cancer pain, at day 28, to study the hypothesis about the long-term pain improvement.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with t methadone for cancer pain in opioid rotation
- •Able to fill the questionnaire
- •Performance status (PS) from 0 to 2
排除标准
- •Patients PS 3
- •Unable to sign the informed consent
结局指标
主要结局
Difference between EVA pain score at Day 28 and Day 0
时间窗: pain score measure at Day 0 and Day 28
long-term effects of methadone for cancer pain
次要结局
- Change in quality of life score QOL C30(Day 0 and Day 28)
- Side effect record(up to Day 28)
- Change in depression and anxiety score HADS(Day 0 and Day 28)
- Change in score of neuropathic pain intensity NPSI(Day 0 and Day 28)