Effect of Mannitol on Optic Nerve Sheath Diameter in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy: a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Change in optic nerve sheath diameters
研究概览
简要总结
We aim to evaluate the change in optic nerve sheath diameters as a surrogate of intracranial pressure before and after mannitol administration in patients who undergo robot assisted laparoscopic radical prostatectomy with pneumoperitoneum and Trendelenburg position.
详细描述
Mannitol has been frequently used for renal protection during surgery. Optic nerve sheath diameter is used to evaluate intracranial pressure noninvasively. Robot-assisted laparoscopic radical prostatectomy can induce an increase in optic nerve sheath diameter due to Trendelenburg position and carbon dioxide insufflation. We therefore aim to evaluate the change in optic nerve sheath diameters before and after mannitol administration in patients who undergo robot assisted laparoscopic radical prostatectomy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 79 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •prostate cancer patients undergoing robot assisted laparoscopic radical prostatectomy.
- •20 year old or above, 79 year old or below.
- •agreed to participate this study.
排除标准
- •history of cerebrovascular accident.
- •history of congestive heart failure.
- •history of pulmonary edema.
- •history of anaphylaxis to mannitol.
- •conversion to open prostatectomy.
- •combined with other operation.
- •inability to measure optic nerve sheath diameter.
结局指标
主要结局
Change in optic nerve sheath diameters
时间窗: 5 minutes after pneumoperitoneum and Trendelenburg position, 90 minutes after mannitol administration during pneumoperitoneum and Trendelenburg position
Change in optic nerve sheath diameters before and after mannitol administration
次要结局
- Change in optic nerve sheath diameters(5 minutes after pneumoperitoneum and Trendelenburg position, 30 minutes after mannitol administration during pneumoperitoneum and Trendelenburg position)
- Optic nerve sheath diameter(Intraoperative (during skin closure))
研究者
Young-Kug Kim
Professor
Asan Medical Center