The Effects of a Dynamic Warm up on the Immune Response to Exercise in Lower Fit and Higher Fit Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Perceived exertion during exercise
研究概览
简要总结
This randomized cross-over study compares two identical cardiorespiratory exercise bouts, differing only in the inclusion or exclusion of a dynamic period of increasing exercise intensity prior to the exercise bout. Planned comparisons include physiological responses and perceived effort during exercise, leukocyte mobilization, and mood between the two exercise sessions.
详细描述
Physically active adult men and women are asked to complete three study visits to the laboratory. On Visit 1, participants provide informed consent and are screened for study inclusion criteria: being between 18 and 40 years of age, a non-smoker, not pregnant, free of disease impacting exercise performance or immunity, and performing at least one hour per week of vigorous exercise training (any modality) for at least the prior six months. Participants also complete an incremental submaximal exercise test on a stationary bicycle. The results of this test are used to calculate the resistance corresponding to 80% of estimated maximal heart rate. Participants return within 2-14 days for Visits 2 and 3. These visits consist of 30 min of bicycling at this resistance. One visit included a 10 min dynamic warm-up prior to the exercise bout. Participants were stratified by sex and randomized such that half of the men and women completed the exercise trial with warm-up during Visit 2.
Heart rate, perceived exertion, and wattage are recorded during each minute of the exercise bouts. Participants donate blood before, immediately after, and 1h after each exercise. Blood is analyzed by flow cytometry to characterize leukocyte subsets. After each exercise session, participants complete surveys assessing mood and affect.
Physiological, immunological, and psychological parameters recorded will be compared within participants between the two experimental exercise sessions using appropriate statistical tests. p<0.05 will be accepted as significant.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •identifies as exercising 1-3 hours per week or more than 6 hours per week, on average (last 6 months)
- •meets American College of Sports Medicine criteria for participation in exercise
排除标准
- •underlying medical problems that contraindicate supervised high intensity exercise
- •past or present history of autoimmune disease, HIV, hepatitis, stroke, or cardiovascular disease
- •chronic/debilitating arthritis
- •central or peripheral nervous disorders
- •asthma, emphysema, or bronchitis
- •bedridden in the past three months
- •history of blood clotting disorders
- •administration of any medication that might affect physiological response to exercise
- •functional or cognitive impairment that would limit exercise performance or prohibit informed consent
- •having any common-cold or influenza like symptoms (scratchy throat, runny nose, inflamed sinuses, frequent sneezing or coughing) in the last 2 weeks
- •pregnancy
- •tobacco use
研究组 & 干预措施
Warm-up, then no warm-up
Participants' visit 2 included 10 minutes of gradually increasing intensity prior to the 30 minute exercise session. Participants' visit 3 consisted of the 30 minute exercise session without a warm-up.
干预措施: Exercise (Behavioral)
No warm-up, then warm-up
Participants' visit 2 consisted of the 30 minute exercise session without a warm-up. Participants' visit 3 included 10 minutes of gradually increasing intensity prior to the 30 minute exercise session.
干预措施: Exercise (Behavioral)
结局指标
主要结局
Perceived exertion during exercise
时间窗: Minutes 1-30 of exercise, recordings made each minute
Rating of perceived exertion measured using the Borg 6-20 scale
CD4 T cell mobilization by exercise
时间窗: Change from resting levels of CD4 T cells after exercise
Number of peripheral blood CD4 T cells
Power during exercise
时间窗: Minutes 1-30 of exercise, recordings made each minute
Wattage produced on stationary bicycle
CD8 T cell mobilization by exercise
时间窗: Change from resting levels of CD8 T cells after exercise
Number of peripheral blood CD8 T cells
Monocyte mobilization by exercise
时间窗: Change from resting levels of monocytes after exercise
Number of peripheral blood monocytes
Natural Killer cell mobilization by exercise
时间窗: Change from resting levels of natural killer cells after exercise
Number of peripheral blood natural killer cells
Heart rate during exercise
时间窗: Minutes 1-30 of exercise, recordings made each minute
Heart rate in beats per minute
次要结局
- Affect after exercise(Measured within 10 minute of end of exercise session)
- Mood after exercise(Measured within 10 minute of end of exercise session)
研究者
Emily C Lavoy
Assistant Profesor
University of Houston