Serum 25-Hydroxyvitamin D Across Obstructive Sleep Apnea Phenotypes With and Without Comorbidities: A Retrospective Comparative Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 269
- 主要终点
- Serum 25-Hydroxyvitamin D Levels Across Study Groups
研究概览
简要总结
This retrospective observational study evaluates the relationship between vitamin D status and obstructive sleep apnea (OSA) in adults. The study includes 269 participants divided into four groups: healthy controls, participants with simple snoring without OSA, patients with OSA without comorbidities, and patients with OSA with comorbidities.
The main objective is to compare serum 25-hydroxyvitamin D [25(OH)D] levels among these groups and to examine whether vitamin D status is associated with the presence and severity of OSA. Demographic characteristics, body mass index, laboratory measurements, and available overnight polysomnography findings are evaluated using existing medical records. The study also examines the distribution of vitamin D deficiency across the study groups and the relationship between vitamin D categories and OSA severity.
详细描述
This retrospective comparative study evaluates serum 25-hydroxyvitamin D [25(OH)D] status across clinically distinct obstructive sleep apnea (OSA) phenotypes. Participants were classified into four groups: healthy controls, symptomatic participants with simple snoring/non-OSA (apnea-hypopnea index [AHI] <5 events/hour), patients with OSA without comorbidities, and patients with OSA with comorbidities. OSA was defined as AHI ≥5 events/hour and categorized as mild, moderate, or severe according to conventional AHI thresholds.
Among patients with OSA, comorbid OSA was defined by the presence of at least one documented chronic condition, including hypertension, diabetes mellitus, cardiovascular disease, dyslipidemia, or hypothyroidism. Demographic and anthropometric characteristics, serum 25(OH)D concentrations, available routine laboratory measurements, and polysomnographic parameters were retrospectively obtained from existing medical records and hospital databases.
The study compares vitamin D status across the four groups and evaluates whether serum 25(OH)D concentrations and vitamin D categories are associated with OSA severity. The study also explores whether differences in vitamin D status across OSA phenotypes persist after accounting for age, sex, and body mass index.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults aged 18 years or older. Participants with available serum 25-hydroxyvitamin D [25(OH)D] measurements. For PSG-evaluated groups, availability of overnight polysomnography data allowing classification according to the apnea-hypopnea index (AHI).
- •Participants meeting the predefined criteria for one of the study groups: healthy control, simple snoring/non-OSA, OSA without comorbidities, or OSA with comorbidities.
排除标准
- •Missing or insufficient data required for study-group classification. Missing serum 25(OH)D measurements. Incomplete polysomnographic data preventing determination of OSA status or severity in PSG-evaluated participants.
结局指标
主要结局
Serum 25-Hydroxyvitamin D Levels Across Study Groups
时间窗: During the retrospective study period (2024-2026)
Serum 25-hydroxyvitamin D \[25(OH)D\] concentrations were compared among healthy controls, simple snoring/non-OSA participants, patients with OSA without comorbidities, and patients with OSA with comorbidities.
次要结局
- Distribution of Vitamin D Status Across Study Groups(During the retrospective study period (2024-2026))
研究者
Bekir Sami Uyanık
Professor of Clinical Biochemistry
Hisar Intercontinental Hospital