NCT01489852已完成4 期
Interest of a Steroid Pre-treatment Prior to IVF Protocol With Ovarian Stimulation by Recombinant FSH and With LH Surge Blockage by Daily GnRH Antagonist
Gemer1 个研究点 分布在 1 个国家目标入组 472 人开始时间: 2006年12月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 472
- 试验地点
- 1
- 主要终点
- number of retrieved oocytes
研究概览
简要总结
The purpose of this study is to assess whether estrogen pre-treatment can allow retrieval of 2 additional oocytes in GnRH antagonist protocol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •regular normo-ovulatory cycles (28 to 35 days)
- •age < 38 years,
- •body mass index (BMI) between 18 and 30
- •first or second IVF/ICSI attempt
排除标准
- •high basal levels of serum FSH or E2,
- •less than 5 follicles at the antral follicular count performed on day 3 of a spontaneous cycle,
- •history of high (>20 oocytes) or low (< 5 oocytes) ovarian response in a previous IVF attempt
研究组 & 干预措施
Estrogen pre-treatment
Active Comparator
干预措施: 17beta-estradiol (Drug)
结局指标
主要结局
number of retrieved oocytes
时间窗: at the ovarian puncture, 36 hours post HCG administration
次要结局
- delivery rate(9 months later)
- number of obtained embryos(2 days after in vitro fertilization)
- pregnancy rate(at pregnancy test and at 6 Week US examination)
- duration of FSH administration(at the end of ovarian stimulation usually after a mean of 12 days of administration)
- Total FSH dose(at the end of ovarian stimulation usually after a mean of 12 days of administration)
研究者
Dr CEDRIN-DURNERIN Isabelle
principal investigator
Gemer
研究点 (1)
Loading locations...
相似试验
已完成
4 期
Programming by Estrogen Treatment in Gonadotropin Releasing Hormone Antagonist ProtocolInfertilityNCT01419353Meir Medical Center63
已完成
不适用
Effectiveness of Estradiol Valerate Pretreatment in Antagonist Protocol for Poor Ovarian Response PatientInfertilityNCT03300518Reproductive & Genetic Hospital of CITIC-Xiangya552
已完成
4 期
Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic FloorPelvic Organ ProlapseMenopauseNCT01778985University of Texas Southwestern Medical Center30
Unknown
1 期
The Influence of Estradiol Supplementation During the Luteal in Patients Undergoing IVF TreatmentInfertilityNCT00490308Assaf-Harofeh Medical Center120
进行中（未招募）
3 期
Effect of Local Estriol Treatment Before Vaginal Repair SurgeryPelvic Organ ProlapsePelvic Floor DisordersVaginal AtrophyMenopauseNCT06391372Hatice Tukenmez Kurnaz36