Effects of a Single Bout of Moderate Intensity Aerobic Cycling Exercise Combined With Virtual Reality on Processing Speed in Persons With Multiple Sclerosis and Mobility Disability
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 23
- 试验地点
- 2
- 主要终点
- Modified Flanker Task (MFT)
研究概览
简要总结
To compare the effects of cycling exercise with different types of virtual reality on processing/thinking speed in persons with multiple sclerosis (MS).
详细描述
The purpose of this research study is to learn how different types of cycling exercise can improve short-term processing speed, or speed of thinking, in persons with MS. In this study, we will compare the effects of cycling alone to cycling with two different types of virtual reality. Participants will complete all three cycling conditions, one per week. We are studying these types of cycling because there are currently no effective treatment options to improve processing speed in persons with MS and combining exercise with virtual reality is a promising technique.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
盲法说明
Participants will be blinded to the hypothesized effect of each exercise condition.
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Speak English as their primary language
- •Confirmed MS diagnosis by a neurologist
- •Be relapse and steroid-free for at least 30 days
- •Mild-to-moderate self-report mobility disability
排除标准
- •History of neurological disorders besides MS or history of uncontrolled psychiatric disorders (ex: major depression)
- •Have contraindications to exercise, based on the Physical Activity Readiness Questionnaire (PAR-Q)
- •Currently use medications that may impact cognition (ex: steroids, benzodiazepines)
- •Currently pregnant
- •Severe cognitive impairment as measured by the Modified Telephone Interview of Cognitive Status (TICS-M)
- •No indication of age-related mild cognitive impairment or dementia, based on the MOCA-Blind (i.e., MOCA-Blind ≥19).
- •High likelihood of motion sickness
- •Regular cyclist, defined as cycling for at least 150 minutes/week
结局指标
主要结局
Modified Flanker Task (MFT)
时间窗: Immediately before the single bout of cycling and 5 minutes after the single bout of cycling.
Response time on a computerized test is conceptualized as a measure of processing speed. Participants are tasked with identifying the direction of the central target stimulus that is flanked by either congruent (\<\<\<\<\<) or incongruent (\>\>\<\>\>) stimuli by pressing the correct keyboard key.
次要结局
- Baseline mobility disability(Baseline visit only)
- Baseline Symbol Digit Modalities Test (SDMT)(Baseline visit only.)
研究者
Carly Wender
Research Scientist
Kessler Foundation