Effects of sildenafil on exercise responses in symptomatic individuals with evidence of tobacco-associated pulmonary microvascular disease: randomized, double-blind clinical trial

niversidade Federal de Mato Grosso do Sul0 个研究点开始时间: 2020年1月22日最近更新: 2023年5月29日

适应症

试验速览

暂无简介。

•Symptomatic vascular phenotype; Individuals of both sexes; Age between 35 and 80 years; History of smoking for more than 10 years; Sinus rhythm; Preserved left ventricular ejection fraction (higher than 50%); The evaluated patients should be able to perform spirometry, carbon monoxide diffusion test and cardiopulmonary exercise test.

•Carrier of diabetes mellitus, bronchial asthma, previous myocardial infarction, heart failure, complex ventricular arrhythmias; Chronic atrial fibrillation; Body mass index lower than 18.5 or higher than 35 kg per m²; Anemia with hemoglobin lower than 11 g% in women and lower than 12 g% in men; Chronic hypoxemia of undetermined cause; neuromuscular, orthopedic or psychological limitation;
•Contraindication to the use of sildenafil citrate or previous use of it thereof.

发起方

niversidade Federal de Mato Grosso do Sul