Can Fatigability Neuromuscular Explain Chronic Fatigue in People With Multiple Sclerosis?
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 67
- 试验地点
- 1
- 主要终点
- Voluntary maximum contraction
研究概览
简要总结
Chronic fatigue is the most common and debilitating symptom in multiple sclerosis patients. This chronic fatigue affects their quality of life by decreasing their capacity to perform simple tasks of daily life.
The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in this feeling of chronic fatigue. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology will allow to optimize rehabilitation treatments to decrease the apparition/persistence of chronic fatigue and in fine improve quality of life.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For Patients:
- •Aged ≥ 18 and ≤ 70 years
- •Men or women
- •With multiple sclerosis since 2 and 25 years
- •Affiliates or beneficiaries of social security scheme
- •Signed consent
- •For Healthy volunteers:
- •Aged ≥ 18 and ≤ 70 years
- •Men or women
- •Matched in accordance with age, sex and level of physical activity
排除标准
- •For Patients and Healthy volunteers:
- •High heart rate resting
- •Blood pressure > 144/94 mmHg
- •Recent adjustment of drug or drug can have an impact on fatigue or stimulant for fatigue
- •Taking neuroactive substances that can alter corticospinal excitability
- •Contraindication at application magnetic field
- •Contraindication at Magnetic Resonance Imaging (MRI)
- •Currently participating in a structured exercise program
- •For Patients only:
- •Spasticity or cerebellar ataxia
- •Abnormal range of motion (toe and/or ankle)
- •Musculoskeletal injuries that impedes pedaling
- •Appearance of symptoms of multiple sclerosis in the 90 days preceding the study
- •For Healthy volunteers:
- •Neurological diseases, cardiovascular, musculoskeletal
结局指标
主要结局
Voluntary maximum contraction
时间窗: Day : 30
Comparison the percentage of decrease in voluntary maximum contraction reported after the fatiguing task. Measured by an instrumented measuring pedal (PowerForce pedal, Model PF1.0.0.0, Radlabor GmbH, Freiburg, Germany)
次要结局
- VO2 max(Day : 30)
- Anemia(Day : 30)
- Thermoregulation(Day : 30)
- Muscle oxygen extraction capacity(Day : 30)
- Heart rate(Day : 30)
- Neuromuscular function during the dynamic strenuous exercise(Day : 30)
- Metabolic fatigue(Day : 30)
- Inflammation(Day : 30)
- Cognitive fatigue(Day : 30)
- Sleep quality(Day : 30)
- Perceived fatigue(Day : 30)
- Muscle volume(Day : 30)