Effect of Dexmedetomidine on cerebral blood flow auto-regulation in patients with intracranial tumours.

Sri Chitra Tirunal Institute for Medical Science and Technology0 个研究点目标入组 30 人开始时间: 待定最近更新: 2021年11月24日

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•two groups (15 patients in each group)
•Group I - patients with unilateral Glioma, Glascow coma scale 15, American society of anesthesiology Grading 1 and 2.
•Group II - patients having no intracranial pathology ( patients posted for lumbar and thoracic spinal cord surgeries (laminectomy, discectomy), American society of anesthesiology Grading 1 and 2.

•Patient refusal, American society of Anesthesiology (ASA) class 3 and above, Age less than 18 years and more than 35 years, Preoperative Glasgow coma scale (GCS) <15, Intracranial vascular abnormalities, Documented cases of Carotid stenosis, atherosclerosis, Infra tentorial / posterior fossa tumours, Emergency surgery, Preoperative heart rate <50 bpm, Systemic hypertension stage III & above, Heart block, Known allergy to Dexmedetomidine, Patient on beta blockers, Coronary artery disease, Left ventricular dysfunction,Pregnant or Nursing woman.
•Antihypertensive medication with alpha-methyldopa, clonidine or other a2-adrenergic agonist, Vascular pathology ( Plaque, calcification, narrowing, stenosis, abnormal flow pattern ) identified during pre-induction sonography, Difficulty in localizing intracranial vasculature by TCCDI, Abnormal bone window, Participation in another drug study during the preceding 1 month period.

发起方

Sri Chitra Tirunal Institute for Medical Science and Technology