Accuracy of Ultrasound Markers Versus Biochemical Markers in Prediction of Ovarian Response in Obese Women Undergoing IVF/ICSI Treatment
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- number of retrieved oocytes
研究概览
简要总结
After detailed history and examination, long luteal protocol will be used for controlled ovarian hyperstimulation, so the patient will start treatment in day 21 of previous cycle, then in the early follicular phase of next cycle day 2-3 will have transvaginal sonography for assessment of total ovarian volume and number of antral follicles measuring (2-10mm) in diameter. On the same day a venous sample will be obtained for the measurement of AMH, basal FSH and E2 levels
详细描述
After detailed history and examination,A transvaginal ultrasound will be done using a transvaginal transducer with 7.5 MHz.
Each ovary will be measured in 3 planes maximal longitudinal, antero-posterior and transverse diameters, D1, D2 and D3 respectively. And ovarian volume will be calculated using the ellipsoid formula:
V = D1× D2 × D3 × 0.523 The volume of both ovaries will be added for the total basal ovarian volume (BOV).
The mean diameter of the antral follicles will be used by measuring the diameter of the follicle in two perpendicular directions.
The total AFC is calculated by counting the follicles with mean diameter 2-10mm in both ovaries.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women between 20 and 35 age.
- •BMI: 30 -35
排除标准
- •Women less than 19 years or more than 35 years.
- •BMI less than 30 or more than 35
- •Women with Hypothyroidism.
- •Women receiving any treatment may reduce their fertility e.g: chemotherapy.
- •Women with recurrent IVF failure
研究组 & 干预措施
obese group
100 obese patients with BMI between 30 and 35 who are undergoing IVF/ICSI treatment for infertility
干预措施: Long luteal phase GnRH agonist protocol (Drug)
obese group
100 obese patients with BMI between 30 and 35 who are undergoing IVF/ICSI treatment for infertility
干预措施: Gonadotropins (Drug)
结局指标
主要结局
number of retrieved oocytes
时间窗: 34 hours after HCG triggering of ovulation
number of oocytes retrieved at day of ovum pick up
次要结局
- Clinical pregnancy rate(14 days after embryo transfer)