NCT00611741已完成1 期
The Role of Cortical Glutamate and GABA in Brains Osmotic Regulation: A Pilot Study in Healthy Volunteers and in Patients With Schizophrenia
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Cortical glutamate concentration
研究概览
简要总结
This study is designed to test the hypothesis that plasma osmolality is linked with cortical glutamate concentrations in the brain. It also investigates whether the glutamate response in schizophrenia is enhanced compared to healthy controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Drug intervention, longitudinal
Experimental
Furosemide and Na supplements
干预措施: furosemide, Na supplements (Drug)
结局指标
主要结局
Cortical glutamate concentration
时间窗: Baseline and endpoint
次要结局
- Cognitive function(Baseline and end point)
研究者
Handan Gunduz-Bruce
Assistant Clinical Professor
Yale University
研究点 (1)
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