Effectiveness of 1L Mannitol Versus 1L Polyethylene Glycol Electrolyte Dispersion as a Salve for Patients With Inadequate Bowel Preparation: a Randomized Controlled Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 134
- 试验地点
- 1
- 主要终点
- Bowel cleanliness
研究概览
简要总结
For patients with inadequate bowel preparation, current guidelines recommend either remedial measures or rescheduling the endoscopy, but previous surveys have found that approximately 30% of patients do not follow medical advice to reschedule the examination if it is rescheduled, while those who take remedial measures on the same day are more compliant, so remedial measures may be a better option than rescheduling the examination. As for the remedy regimen, it has been demonstrated that oral PEG is superior to the enema regimen in terms of bowel cleansing, but PEG is very resistant to be taken by most patients due to its poor taste and the larger doses required, resulting in poor bowel preparation and poor compliance. In contrast, oral mannitol has the advantages of small dose and good taste, and patient compliance may be higher.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 75 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 18-75 years with a pre-first colonoscopy bowel cleanliness of less than 2 points in any segment of the bowel.
排除标准
- •(1) Pregnant women. (2) History of colorectal surgery. (3) Patients with acute exacerbation of inflammatory bowel disease. (4) Patients with severe medical conditions that make them unsuitable for colonoscopy.
- •(5) Patients with known allergy to mannitol/PEG. (6) Patients who refuse to sign the informed consent form.
研究组 & 干预措施
Mannitol
Use of oral 1L Mannitol for remediation of intestinal uncleanliness
干预措施: Mannitol (Drug)
Polyethylene glycol electrolyte
Use of oral 1L PEG for remediation of intestinal uncleanliness
干预措施: Polyethylene glycol electrolyte (Drug)
结局指标
主要结局
Bowel cleanliness
时间窗: 1 hour
The BBPS scoring method, defined as a score of ≥2 for each bowel segment, was used to consider the preparation adequate.
次要结局
- Patients' feelings(1 hour)
