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临床试验/CTRI/2026/02/102928
CTRI/2026/02/102928尚未招募不适用

GI GEC rectal brachy dose reporting project

Maastricht Radiation Oncology Maastro Clinic1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2026年4月6日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
100
试验地点
1

研究概览

简要总结

This study aims to identify robust dose volume and depth dose metrics for dose reporting in rectal high dose rate brachytherapy. The primary purpose of the protocol is to evaluate dosimetric parameters that are sensitive to clinically relevant variations in dose distribution while remaining stable against unavoidable delineation uncertainties, contouring variability, and differences between treatment planning systems.

The study will collect and analyze dose volume histogram based parameters from rectal brachytherapy treatment plans generated at multiple centers using different applicators and planning systems. Candidate metrics will be assessed for their ability to reflect differences between treatment plans and patients, as well as their robustness to contouring variation and dose calculation differences.

The underlying hypothesis of the study is that a limited set of dose volume metrics can be identified that consistently represent dose distribution characteristics in rectal high dose rate brachytherapy and can be reliably recorded and reported across centers. The findings of this study are expected to support the development of standardized dose reporting guidelines and facilitate improved consistency in clinical practice and future research.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 80.00 Year(s)(—)
性别
All

入选标准

  • Rectal cancer patients who have been treated with rectal high dose rate brachytherapy at participating centers.
  • Availability of complete treatment planning data including dose volume histogram information.
  • Treatment plans generated using clinically approved treatment planning systems.
  • Cases where target and relevant structures are delineated according to the specified delineation guideline or can be updated accordingly.

排除标准

  • Cases with incomplete or missing treatment planning or dose volume histogram data.
  • Treatment plans not suitable for dose volume histogram analysis due to technical limitations.
  • Cases where required delineation structures are unavailable and cannot be reconstructed or updated.

研究者

发起方
Maastricht Radiation Oncology Maastro Clinic
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Rahul Krishnatry

Tata Memorial

研究点 (1)

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