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临床试验/CTRI/2026/02/103972
CTRI/2026/02/103972尚未招募不适用

Effects Of Strength Training Versus Endurance Training On Hepatic Steatosis, Function, Central Adiposity And Quality Of Life In Individuals With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

Krupa Prabhu1 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2026年2月28日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
36
试验地点
1

研究概览

简要总结

Non-alcoholic fatty liver disease (NAFLD), recently termed metabolic dysfunction–associated steatotic liver disease (MASLD), is a common metabolic liver disorder associated with obesity, insulin resistance, and increased cardiometabolic risk. Structured exercise is recommended as the primary management strategy; however, evidence comparing different exercise modalities remains limited. This randomized clinical trial aims to compare the effects of strength training (calisthenics) and endurance training (aerobic exercise) on hepatic steatosis, liver function, central adiposity, and quality of life in adults with NAFLD. A total of 36 participants aged 25–50 years will be randomly allocated into two groups, one receiving supervised strength training (calisthenics) and the other receiving supervised aerobic exercise. Both interventions will be administered three times per week for eight weeks. Outcome measures including ultrasound grading of hepatic steatosis, liver enzymes (ALT and AST), waist–hip ratio, and quality of life will be assessed before and after the intervention period. The findings of this study may help identify an effective and accessible exercise-based intervention for the management of NAFLD

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Outcome Assessor Blinded

入排标准

年龄范围
25.00 Year(s) 至 50.00 Year(s)(—)
性别
All

入选标准

  • Individuals of all genders aged 25-50 years diagnosed with Non-Alcoholic Fatty Liver Disease by a Gastroenterologist.
  • Ultrasound confirmed Grade 1-2 hepatic steatosis.
  • Body Mass Index (BMI) between 25-35 kg per m2, indicating overweight or class 1 obesity.
  • Elevated or borderline liver enzyme levels ( ALT and or or AST), ALT greater than 56 units per liter and or or AST greater than 40 units per liter.
  • Willingness to participate and provide Informed Consent.

排除标准

  • Alcohol intake greater than 21 units per week (men) or greater than 14 units per week (women).
  • Other liver diseases or cirrhosis
  • Uncontrolled cardiovascular, respiratory, or endocrine disorders.
  • Participants with a history of regular exercise
  • Musculoskeletal limitations preventing exercise.
  • Use of hepatotoxic or lipid-lowering medications (e.g., corticosteroids, statins)
  • Pregnancy or lactating.

研究者

发起方
Krupa Prabhu
申办方类型
Other []
责任方
Principal Investigator
主要研究者

Krupa Prabhu

KAHER Institute of Physiotherapy, Belagavi

研究点 (1)

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