Health Effects of Oat and Oat Bioactive in Human
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Blood glucose regulation
研究概览
简要总结
Aim of the study is to investigate health effects of oats and oat derived components, in human intervention studies, with the purpose to build new knowledge for development of cardiometabolic protective foods.
详细描述
The overall goal is to increase the knowledge which can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people. More specifically the primary purpose of this project is to evaluate effects in healthy humans on cardiometabolic test markers of oat and oat based product. The new knowledge will form a base for the development of oat based food products with added health values.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults
- •BMI 18.5 - 28 Kg/m2
- •Non smokers
- •Consuming a non-vegetarian diet that follows the Nordic diet recommendation.
排除标准
- •Fasting blood glucose concentration >6.1 mmol/l
- •Known cardio-metabolic disease (e.g. diabetes, hypertension, metabolic syndrome).
- •Gastro-intestinal disorders such as IBS (irritable bowel syndrome) that can interfere with the study results, food allergies.
- •No antibiotics or probiotics should have been consumed within 4 weeks prior to and during the study.
结局指标
主要结局
Blood glucose regulation
时间窗: 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch)
Postprandial blood glucose regulation (incremental area under the curve) acute after intake of the test products and at forthcoming meals within 5.5 hours after consumption of test products.
次要结局
- Serum insulin(0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch))
- Serum triglycerides(0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch))
- Serum Free Fatty Acids(0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch))
- Plasma PYY (peptide tyrosine tyrosine)(0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch))
- plasma GLP-1 (glucagon-like peptide-1 )(0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch))