Sleep Disordered Breathing in Children With Single Ventricle Physiology

This is an exploratory study designed to evaluate the incidence of, and to quantify sleep disordered breathing following stage I Norwood reconstructive surgery. Sleep disordered breathing will be correlated with:

1. Elevations in pulmonary vasculature resistance at the time of Stage II surgery.
2. Risks of death

Children with single ventricle physiology are exquisitely sensitive to alterations in pulmonary vascular resistance. Following their first operative repair (stage I Norwood), performed in their first week of life, pulmonary and systemic circulations are in parallel rather than series. As such, elevations in pulmonary vascular resistance can result in severe arterial desaturation. Additionally, elevated pre-operative pulmonary artery pressure is directly correlated with poor survival following the third and final operative repair (stage III Norwood, or Fontan).

Periodic breathing is a normal breathing pattern in sleeping infants. At the other end of the spectrum is sleep apnea. In between lies a continuum of sleep disordered breathing. Obstructive sleep apnea has an incidence of approximately 2% in children, and is associated with pulmonary and systemic hypertension. Specific studies of the incidence and effects of sleep disordered breathing in congenital heart disease are lacking. Otherwise normal children have baseline oxygen saturation in the high 90's, thereby placing them on the flat part of the oxyhemoglobin curve. But children with cyanotic congenital heart disease live with baseline oxygen saturations in the mid 70's, so that they exist on the steep part of the oxyhemoglobin dissociation curve. We hypothesize therefore that these patients are at increased risk for the hemodynamic variations occurring during apneas/hypopneas even when they are more subtle, namely during sleep disordered breathing.

We hypothesize that children who have completed stage I Norwood will experience more significant arterial desaturations during sleep associated apneic events (due to the concurrent elevation in pulmonary arterial pressure) than their normal counterparts. Additionally we hypothesize that children who experience more frequent apneic events during sleep will have elevated pre-operative pulmonary artery pressures and therefore worse outcome following stage II Norwood. Thus, we speculate that children who have completed stage I Norwood are more prone to the risks of sleep disordered breathing.