Pulmonary Vascular Disease and Cardiac Performance in Extreme Preterm Infants: A Prospective Cross-sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Heart function by echocardiography
研究概览
简要总结
Pulmonary vascular disease and cardiac performance in extreme preterm infants: A prospective cross-sectional study
详细描述
The principal investigator hypothesize that premature newborns have disturbed cardiac performance and increased pulmonary pressures during neonatal life and at different pediatric ages.
The principal investigator also hypothesize that premature newborns with poor cardiac performance and/or pulmonary hypertension have higher morbidities and poorer neuro-developmental outcomes.
The principal investigator also hypothesize that premature newborns with poor cardiac performance and/or pulmonary hypertension have higher morbidities and poorer neuro-developmental outcomes and that novel echocardiography techniques will detect anomalies not uncovered by conventional imaging, and that early echocardiography may identify those with later pulmonary hypertension.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 7 Days 至 5 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Infants born at <29 weeks' gestational age admitted to the NICU
- •All infants born at <29 weeks' gestational age followed at MCH clinic after an admission in the NICU for prematurity <29 weeks
排除标准
- •Congenital heart disease (except an atrial (ASD) or ventricular septal defect (VSD), or a patent ductus arteriosus (PDA))
- •Congenital severe lung or airway malformation (choanal atresia, trachea-esophageal fistula or congenital pulmonary airway malformation)
- •Genetic disorder (Trisomy 21).
结局指标
主要结局
Heart function by echocardiography
时间窗: 5 years chronological
STE allows for calculation of strain (absolute deformation) of segmental areas of the heart to provide insight on cardiac performance
次要结局
- Neuro-developmental profile(5 years chronological)
研究者
Gabriel Altit
Neonatologist
McGill University Health Centre/Research Institute of the McGill University Health Centre