NCT00163150已完成4 期
Lacunar-Brain Infarction Cerebral Hyperactivity And Atorvastatin Trial. A Placebo-Controlled Trial Of High-Dose Atorvastatin In Patients With Cerebral Small Vessel Disease.
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.2 个研究点 分布在 1 个国家目标入组 128 人开始时间: 2003年6月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 128
- 试验地点
- 2
- 主要终点
- Evaluate the efficacy of atorvastatin treatment during 3 months (80mg/day) on cerebral vasoreactivity (CVR) in lacunar patients. CVR, humeral and carotid vasoreactivity will be measured in all patients at M0 and M3.
研究概览
简要总结
The main purpose of this study is to evaluate the efficacy of atorvastatin treatment during 3 months (80mg/day) on cerebral vasoreactivity (CVR) in lacunar patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •clinically defined lacunar syndrome 3 months before inclusion
- •small deep infarct on diffusion MRI (Diffusion Weighted Imaging)
- •no atherothrombotic, cardio-embolic, or other rarer cause.
排除标准
- •patients with past coronary event
- •contra-indication for assessment of vasomotor reactivity
- •patients being on statin therapy at the time of brain infarction
- •contra-indication for statin therapy
- •patient still under statin therapy
结局指标
主要结局
Evaluate the efficacy of atorvastatin treatment during 3 months (80mg/day) on cerebral vasoreactivity (CVR) in lacunar patients. CVR, humeral and carotid vasoreactivity will be measured in all patients at M0 and M3.
次要结局
- Evaluate the efficacy of atorvastatin treatment during 3 months (80mg/day) on endothelium dependant and independent vasomotoricity of humeral and / or common carotid artery (according to validation study) in lacunar patients.
研究者
研究点 (2)
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