Prognosis of a First-Ever Stroke in Persons Living With HIV
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 4
- 试验地点
- 1
- 主要终点
- degree of disability measured with the modified Rankin Scale
研究概览
简要总结
With aging of the persons living with HIV, cardiovascular diseases now account for substantial mortality and morbidity. Stroke frequency grows exponentially with aging and its incidence doubles every decade over 55 years of age.
The prognosis of ischemic stroke depends mainly on the care in Stroke Units in the acute phase of the disease (thrombolysis/thrombectomy). It is important that HIV patients are referred to these units in the first hours of a stroke and not to their infectious disease units which is a loss of chance.
It would also be important to know whether HIV patients need specific protocols for stroke emergency management.
The study aims to compare the functional prognosis after the first occurrence of an ischemic stroke, in patients admitted to a Stroke Unit, whether they are infected or not infected by HIV.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients unexposed to HIV: HIV-1 seronegative OR patients exposed to HIV: HIV seropositive for over 6 months with or without antiretroviral treatment. Confirmed by Elisa and Western blot tests
- •admitted for ischemic stroke, defined as a sudden cerebrovascular event confirmed by MRI
- •at least 18 years of age
- •paired with patients unexposed to HIV, admitted for ischemic stroke, same gender and age
排除标准
- •antecedents of a symptomatic ischemic or hemorrhagic cerebrovascular event
- •no social security benefits;
- •Absence of signed informed consent for the study
- •Patients currently pregnant or breast-feeding
结局指标
主要结局
degree of disability measured with the modified Rankin Scale
时间窗: 3 months
次要结局
未报告次要终点