Effect of Monitoring of Pulse Index Continuous Cardiac Output on Shock Patients in ICU
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 320
- 试验地点
- 1
- 主要终点
- mortality at 28 days
研究概览
简要总结
PiCCO has become a widely used haemodynamic monitoring device in the management of shock patients in ICU patients nowadays. But the effects on outcome of use of Picco, such as hospital mortality, vasoactive agents-free days, intensive care unit, and mechanical ventilation-free days and change of lactate and BNP in shock patients has not been determined. Patients will be randomly assigned to a Picco group or the control group, hospital mortality, vasoactive agents-free days, intensive care unit, and mechanical ventilation-free days and change of lactate and BNP will be observed. The conclusion will supply evidence for the clinical effectiveness of Picco in shock patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •critically ill patients with shock: Mean arterial pressure (MAP) < 65 mmHg (< 8,7 kPa) or systolic arterial pressure (SAP) < 90 mmHg (< 12 kPa) or the need for vasopressor (Norepinephrine <0.05µg/kg/min) to support the MAP ≥ 65 mmHg (≥ 8,7 kPa) or the SAP ≥ 90 mmHg ≥ 12 kPa), when one of these criteria has lasted for 4 hours or longer
排除标准
- •Age < 18 years
- •Age > 85 years
- •Pregnancy (positive pregnancy test in women of child bearing age)
结局指标
主要结局
mortality at 28 days
时间窗: 28 days
mortality at 28 days after diagnosis of shock
次要结局
- vasoactive agents-free days(28 days)
- intensive care unit-free days(28 days)
- mechanical ventilation-free days(28 days)
- the change of lactate at 1,3,7 days after the insertion of the Picco catheter(7 days)
- the change of B-Type Natruetic Peptide(BNP) at 1,3,7 days after the insertion of the Picco catheter(7 days)
- mortality at 90 days(90 days)
研究者
Li danyang
Dr
Zhejiang University