Nomogram for Preoperative Estimation of Microvascular Invasion Risk in Hepatocellular Carcinoma
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 370
- 主要终点
- Presence of microvascular invasion
研究概览
简要总结
Presence of microvascular invasion can be estimated preoperatively, by some clinical imaging features such as patient characteristics, serum biomarkers and radiological features. Contrast-enhanced ultrasonography (CEUS) and contrast-enhanced computed tomography (CECT) are routine preoperative conventional examinations for hepatocellular carcinoma (HCC) patients in China. Combining features of CEUS, CECT and clinical factors may improve preoperative MVI assessment. The purpose of this study is to construct a nomogram for preoperative MVI risk estimation with these possible factors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Asian patients aged 18～80 years old;
- •With no preoperative anti-cancer treatment;
- •Scheduled for radical liver resection;
- •With both CEUS and CECT performed in 4 weeks before surgery;
- •Postoperative histologically confirmed HCC;
- •With sufficient surgical specimen for MVI detection (surgical margin ≥1cm);
排除标准
- •Recurrent HCC or combined hepatocellular-cholangiocarcinoma;
- •With extra-hepatic metastasis or macrovascular invasion;
- •With incomplete clinical and imaging data;
- •Non-radical resection;
结局指标
主要结局
Presence of microvascular invasion
时间窗: Through patient enrollment completion, an average of 2 years
Postoperative histologically confirmed microvascular invasion
次要结局
未报告次要终点
研究者
Ming Kuang
Professor
Sun Yat-sen University