EUCTR2007-000030-39-NL进行中（未招募）不适用
Prazosin as add-on therapy in the pharmacological treatment of sleep disturbances in post traumatic stress disorder, a placebo-controlled study using polysomnography - prazosin in the treatment of PTSD related sleep disturbances
Ministery of Defense, Military Mental Health - Research Centre0 个研究点目标入组 30 人开始时间: 2007年8月9日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- Male
入选标准
- •-Age between 18 - 65
- •-Veterans or active military personnel
- •-History of deployment
- •-Subjects have to meet DSM-IV criteria for PTSD, as measured by SCID, with a CAPS score of > 50
- •-PSQI scores of > 10
- •-SSRI treatment for at least 6 weeks at stable and adequate dosage
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •-Substance or alcohol abuse/ dependence within the past six months
- •-Major systemic or neurological diseases
- •-Organic sleep disorders (sleep apnea syndrome, periodic limb movement disorder, narcolepsy)
- •-Orthostatic hypotension before treatment, defined as a fall in systolic blood pressure of more then 20mmHg, or a fall in diastolic blood pressure of more then 10 mmHg after 2 minutes standing.
- •-Use of psychotropic medication, other than a SSRI, or hypertensive agents.
- •-Chronic benzodiazepine use. Benzodiazepine use on demand has to be stopped at least two weeks before the study. A patient will only be included if no rebound insomnia has been noticed prior to the study.
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