跳至主要内容
临床试验/NCT04643171
NCT04643171Unknown不适用

Markers of Oxidative Stress in Response to Electroacupuncture Against Aerobic Physical Activity in Diabetic Patients

Cairo University1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2020年11月19日最近更新:
适应症

试验速览

阶段
不适用
入组人数
60
试验地点
1
主要终点
superoxide dismutase

研究概览

简要总结

OS is an important pathogenetic mechanism for the development of T2DM and its complications.

Oxidative stress is an imbalance of the generation of free radicals or known as reactive oxygen species (ROS) and reactive nitrogen species [RNS]) and their neutralization by the antioxidant mechanisms.

Increased levels of ROS and RNS lead to damage of lipids, proteins, and DNA, ultimately causing the destruction of the islet cells of pancreas through apoptosis . Elliptical trainer device is a relatively new modality of exercise and is advertised to be superior to a treadmill because of the low joint impact and the more reasonable costs of an elliptical trainer compared to a treadmill . Additional quantative research is needed to further evaluate the effectiveness of elliptical trainers and the physiological and perceptual responses to the machine Electroacupuncture (EA) is a treatment form of traditional acupuncture in which small electrical currents are passed through needles inserted into the subject's skin using EA stimulator. It seems to have more acceptable results and effects on many important clinical applications and medical research sets .

详细描述

60 diabetic patients will be randomly divided to electroacupucture group (30 patients) and high intensity elliptical training (30 patients). the treatment will be done for 5 sessions per week for 12 weeks

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
65 Years 至 80 Years(Older Adult)
性别
All
接受健康志愿者

入选标准

  • type 2 diabetic elderly
  • Body mass index less than 30 kg/m
  • Fasting blood more than 126 mg/dl

排除标准

  • cardiac patients
  • renal patients
  • respiratory patients
  • liver patients
  • patients who received any complementary therapies within 3 past months

结局指标

主要结局

superoxide dismutase

时间窗: It will be measured after 12 weeks

marker of anti-oxidative stress

次要结局

  • nitric oxide(It will be measured after 12 weeks)
  • lipid hydroperoxidase(It will be measured after 12-week training)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ali Mohamed Ali ismail

lecturer of Physical Therapy for Cardiovascular / Respiratory Disorder and Geriatrics, Faculty of Physical Therapy, Cairo University

Cairo University

研究点 (1)

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