Remediation of Cognitive Dysfunction in Euthymic Bipolar Disorder Patients Using Transcranial Direct Current Stimulation (tDCS)
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Total correct responses.
研究概览
简要总结
This study aims to investigate the potential for Transcranial Direct Current Stimulation (tDCS) to enhance cognitive functioning in euthymic bipolar patients through comparing the effect of active or sham tDCS (placebo control) during the performance of two cognitive tasks. The investigators hypothesize that task performance will be improved with active relative to sham tDCS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participants will be right-handed subjects aged 18-65 meeting DSM-IV diagnostic criteria for bipolar disorder, with no acute episodes of depression or mania within the previous 12 weeks
- •A score of ≤ 20 on the MADRS, and a score of ≤ 6 on the YMRS, who have been on a stable dose of mood stabiliser medications for at least 1 month.
排除标准
- •Patients with high suicide risk
- •Co-morbid DSM-IV diagnosis of any psychotic disorder (current or within the last year), schizophrenia and schizoaffective disorder
- •Mental retardation
- •A history of drug or alcohol abuse or dependence within the last 3 months
- •Co-morbid attention deficit hyperactivity disorder (ADHD), or any neurological disorder
- •Recent stroke
- •Head injury
- •History of seizure, or who have had electroconvulsive therapy (ECT) within the 6 months preceding enrolment.
- •Participants will also be excluded if currently taking medications known to be associated with frank cognitive impairment (e.g., benzodiazepines).
研究组 & 干预措施
Sham transcranial direct current stimulation
干预措施: Transcranial direct current stimulation (Eldith DC Stimulator) (Device)
Transcranial direct current stimulation
干预措施: Transcranial direct current stimulation (Eldith DC Stimulator) (Device)
Different transcranial direct current stimulation montage
干预措施: Transcranial direct current stimulation (Eldith DC Stimulator) (Device)
结局指标
主要结局
Total correct responses.
时间窗: Across each session (approximately 1 hour in duration), with each session conducted at least 1 week apart.
Total number of correct responses on each task in each session.
次要结局
未报告次要终点