Identifying the link between bone remodeling markers and muscle function and metabolism in older-adults : effects of exercise

Victoria University0 个研究点目标入组 48 人开始时间: 2018年10月25日最近更新: 2019年10月7日

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•Males and females aged >60 years. Females in particular will be required to be a minimum of 12 months post menopause

•-Any fractures in the previous 3 months, or are currently undergoing a new osteoporotic treatment within 3months or have begun taking anti-resorptive medications within 3months.
•-have diabetes mellitus or are taking hyperglycaemic medications. This is because of the close interaction and effects of osteocalcin and glucose metabolism.
•-any haematological, myelodysplastic or myoproliferative disorder
•-any bone malignancy
•-taking warfarin of vitamin K supplementation or restriction
•-a Body mass index greater than 40kg/m2
•-Engagement in resistance exercise regime more than 2 sessions per week.
•Additional criteria include:
•-are unable to give informed consent independently, we will not include any persons who are unable to give independent informed consent for safety reasons, particularly as we take some invasive measures.
•-pregnancy, it is remains unclear the effects of maximal exercise whilst during pregnancy, as such for safety reasons we will not include pregnant women.
•-unable to understand English, this could potentially be a safety concern if unable to communicate during some of the maximal exertion testing visits, and for the acute exercise bout.

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