Brain Circuitry of Inhibitory Control: Effects of Modulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 117
- 试验地点
- 2
- 主要终点
- fMRI connectivity at rest
研究概览
简要总结
Inhibitory control is relevant to many clinical disorders, including substance abuse/dependence, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder. This proposal is designed to assess brain networks related to response inhibition in healthy young adults, and use neuromodulation to change these networks and behavioral performance on a response inhibition task. Having an understanding of the brain mechanisms involved in response inhibition may enable us to improve pre-existing treatments for disorders with inhibitory control difficulties.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 25 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Low (<1sd below the mean on the BRIEF-Inhibit) or high (>1sd above the mean on BRIEF-Inhibit scale)
- •English fluency to ensure comprehension of study measures and instructions.
排除标准
- •Presence of medical conditions contraindicated for tDCS, including history of any known intracranial pathology, epilepsy or seizures, traumatic brain injury, brain tumor, stroke, implanted medical devices, current pregnancy or women of childbearing age not using effective contraception, or any other serious medical conditions or health problems that would interfere with participation (e.g., skin condition)
- •Inability to undergo MRI
- •Current substance abuse disorder
- •Currently prescribed psychiatric medications.
- •Active mania or psychosis
研究组 & 干预措施
Cautious Participants
Participants who have low scores on a self-report of inhibitory control abilities (BRIEF-Inhibit).
Impulsive Participants- Active Stimulation
Participants who have high scores on a self-report of inhibitory control abilities (BRIEF-Inhibit) who are randomized to active stimulation.
干预措施: Transcranial direct current stimulation (Device)
Impulsive Participants- Sham Stimulation
Participants who have high scores on a self-report of inhibitory control abilities (BRIEF-Inhibit) who are randomized to sham stimulation.
干预措施: Transcranial direct current stimulation (Device)
结局指标
主要结局
fMRI connectivity at rest
时间窗: 2 weeks
Changes in resting state connectivity of the inhibitory control information
fMRI connectivity during a stop signal task
时间窗: 2 weeks
Changes in task-based connectivity on the stop signal task
次要结局
未报告次要终点