Role Of Human Papilloma Virus In Male Infertility In Qena Government - Upper Egypt
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Investigation of Human Papilloma Virus infection in infertile males
研究概览
简要总结
Infertility is a major health problem worldwide and is estimated to affect 8-12% of couples in the reproductive age group.
Infertility affects both men and women. Male causes for infertility are found in 50% of these couples.
HPV may infect the semen ,allowing it to affect male fertility in a variety of ways.
详细描述
WHO defines infertility as the inability to conceive after at least 12 months of regular, unprotected sexual intercourse.
Reduced male fertility can be the result of congenital and acquired urogenital abnormalities, infections of the male accessory glands, increased scrotal temperature (varicocele), endocrine disturbances, genetic abnormalities and immunological factors ,
In 40-60% of cases the only abnormality is the semen analysis and there is no relevant history or abnormality on physical examination and endocrine laboratory testing (idiopathic male infertility).
Semen analysis reveals a decreased number of spermatozoa (oligozoospermia), decreased motility (asthenozoospermia) and many abnormal forms on morphological examination (teratozoospermia). Usually, these abnormalities come together and are described as the OAT-syndrome (oligo-astheno-teratozoospermia).
Human papillomavirus (HPV) is one of the most common sexually transmitted viruses, and males and females from different regions are generally susceptible.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 23 Years 至 53 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Patients with at least 1 year of unprotected sexual intercourse without conception.
- •Patients with genital warts
排除标准
- •Hypergonadotropic/hypogonadotropic hypogonadism
- •Azoospermia
- •chromosome abnormalities
- •undescended testis
- •mumps orchitis
结局指标
主要结局
Investigation of Human Papilloma Virus infection in infertile males
时间窗: 2 Days
Investigation of Human Papilloma Virus (HPV) infection in infertile males as : all participants in the study made semen analysis and the semen were collected by masturbation after 5-7 days of abstinence. Semen parameters (semen volume, sperm concentration, progressive motility (PR) and rate of normal sperm morphology) were analyzed in a thermostat console after semen liquefaction. then Seminal Detection of HPV antibodies in infertile male by HPV ELISA Kit and also to see its effects on semen parameters in Qena government.
次要结局
未报告次要终点
研究者
Mohammed Abderlraheem Abdellatif
Resident at Dermatology , venereology and andrology, Faculty of medicine
South Valley University