Find Out the Deciding Factor of Neuromuscular Blocker Dose for Deep Neuromuscular Blockade
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 主要终点
- the highest correlation coefficient
研究概览
简要总结
Find out the deciding factor(total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) of neuromuscular blocker dose for deep neuromuscular blockade.
详细描述
Before the surgery, total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index were measured by height and weight and skeletal muscle mass and body fat were measured by Bioelectrical impedance analysis (InbodyH20N). Find the highest correlation between the 8 factors (total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) and the amount of rocuronium administered to deep neuromuscular blockade.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients aged 20-80 and American Society of Anesthesiology Physical Grade (ASA) I-II, who undergo laparoscopic surgery for at least 2 hours under general anesthesia
排除标准
- •kidney disease (GFR<60)
- •allergy to study drugs
- •decline participation
- •side effect of propofol and remifentanil
- •when anesthesia does not maintain the level of alertness (BIS) below 60 even when the anesthetic dose is increased, or when hemodynamic instability such as bradycardia and hypotension appears
研究组 & 干预措施
deep neuromuscular blockade
patients who underwent surgery with deep neuromuscular blockade
干预措施: deep neuromuscular blockade (Drug)
结局指标
主要结局
the highest correlation coefficient
时间窗: preoperative 1 days to postoperative 1 days
the relationship of rocuronium for deep neuromuscular blockade and 8 factors (corrected body weight, ideal body weight, lean body weight, fat-free mass, body mass index, skeletal muscle mass, body fat)
次要结局
- onset time of rocuronium(preoperative 1 days to postoperative 1 days)
- Time to deep neuromuscular blockade(preoperative 1 days to postoperative 1 days)
- Recovery time(preoperative 1 days to postoperative 1 days)
研究者
JiWon Han
principal investigator
Seoul National University Bundang Hospital