NCT04328389尚未招募不适用
Periodontal Management in Hypertensive Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- Systolic and Diastolic Blood Pressure Change
研究概览
简要总结
Treated hypertensive patients with any form of periodontal diseases will be randomized to either supragingival dental plaque removal using electric toothbrushes at home or intensive professional oral hygiene treatment and the effects on blood pressure will be identified.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Treated hypertension
- •Have at least 20 natural teeth
- •Presence of any form of periodontal diseases according to guidelines
- •Absence of other significant oral infections.
排除标准
- •Secondary hypertension (known plasma renin screening, abdominal ultrasound with doppler and other investigations)
- •Individual is pregnant or nursing
- •Primary pulmonary hypertension
- •Professional oral hygine within past 6 months
- •Flu, rhinitis, sinusitis etc. within past 4 weeks
- •Use of antibiotics within past 4 weeks
- •Hospitalization for any reason within the past 3 months
- •Allergic disorders; History of chronic infectious disease,
- •Chronic hepatitis B or C infection
- •Chronic Obstructive Pulmonary Disease (COPD), tuberculosis
- •Other known chronic inflammatory or autoimmune condition such as lupus or rheumatoid arthritis, ulcerative colitis or Crohn's disease
- •Use of systemic or local steroids or immunosuppressive agents within 6 months of the inclusion.
- •History of alcohol abuse or unwillingness to limit alcohol consumption to less than 4 drinks per week
结局指标
主要结局
Systolic and Diastolic Blood Pressure Change
时间窗: 1 week
Ambulatory Blood Pressure Monitoring
次要结局
- Systolic and Diastolic Blood Pressure Change(1 week)
研究者
Davide Pietropaoli
junior researcher
University of L'Aquila
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