Role of Multislice Computed Tomography (MSCT) Chest in Differentiation Between Chronic Obstructive Pulmonary Disease(COPD) Patients According to Their Smoking Status
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 90
- 主要终点
- Number of participants with criteria of severe COPD
研究概览
简要总结
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality all over the world. Smoking is considered as an important risk factor, but other risk factors are present. Around 30 % of patients with COPD are non-smokers.
Cessation of smoking in patients with COPD causes decreases the presence of micronodules and other criteria of CT chest.
In last few years, some researchers reported that cessation of smoking raise the apparent extent of emphysema. The cause is not obvious, but this paradoxical fall in lung density is thaught to be resulting from decrease in inflammation after smoking cessation.
CT chest criteria of COPD in active smokers, non-smokers and ex-smokers seem to be different.
So, comparison between CT chest Criteria of COPD in smokers, ex-smokers and non-smokers will be searched in this study to detect the role of multislice computed tomography (MSCT) chest in differentiation between COPD patients according to their smoking status.
详细描述
Basic ethical principles of medical research; beneficence (do well), non-maleficence (do no harm), respect and distributive justice were implemented. The study will be carried out in accordance with the Declaration of Helsinki and the principles of good clinical practice.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients with chronic obstructive Pulmonary Disease.
- •Patients above 18 years.
排除标准
- •Patients with unclear smoking history.
- •Patients with active pneumonia.
- •Patients with acute COPD exacerbation.
结局指标
主要结局
Number of participants with criteria of severe COPD
时间窗: 18 months
Criteria of severe COPD include emphysematous bullae, thick bronchial walls.
次要结局
未报告次要终点
研究者
Somaia Ahmad AbdAllah Ahmad
Main investigator
Assiut University