ISRCTN64506738已完成不适用
Effects of NMDA-receptor antagonism on hyperalgesia, opioid use, and pain after major surgery in young and elderly patients
niversity Health Network, Toronto (Canada)0 个研究点目标入组 132 人开始时间: 2005年9月26日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 132
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Male
入选标准
- •1. Able to read and write English
- •2. Age 18 - 54 years or greater than 55 years, male
- •3. American Society of Anesthesiologists (ASA) class 1 to 3
- •4. Scheduled for elective radical prostatectomy
- •5. Body weight between 60 and 90 kg, Body Mass Index (BMI) less than or equal to 30
排除标准
- •1. Significant Central Nervous System (CNS), respiratory, cardiac, hepatic, renal or endocrine dysfunction and/or any significant sequelae
- •2. Contraindications allergies to, and/or past adverse reactions to opioid analgesics or amantadine
- •3. History of Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) axis I disorder or cognitive dysfunction
- •4. History of epilepsy or other seizures
- •5. History of chronic pain of at least 6 months duration
- •6. History of long-term opioid use for chronic pain
- •7. History of long-term use of amantadine or other antiparkinsonian drug
- •8. Ingestion of antiussive medication within 48 hours before surgery
- •9. History of alcohol or drug dependency/abuse of at least 6 months duration
研究者
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