EUCTR2010-020240-35-DE进行中（未招募）不适用
Significance of the FSH receptor polymorphism p.N680S for the efficacy of FSH therapy of idiopathic male infertility: a pharmacogenetic approach.
niversity of Modena and Reggio Emilia0 个研究点目标入组 100 人开始时间: 2011年12月19日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- Male
入选标准
- •- age 20-50 years
- •- idiopathic male factor infertility for at least one year;
- •- homozygous FSHR allele at codon 680 (wild type: Asn/Asn or Ser/Ser);
- •- sperm DNA fragmentation index (DFI) > 15%;
- •- normal serum FSH levels (< 8 IU/L)
- •- normal serum LH, testosterone, prolactin and estradiol levels
- •- normal ovulatory female partner
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 100
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •- azoospermia
- •- all known aetiologies of male infertility (endocrine disorders, genetic disorders, chromosome abnormalities, congenital bilateral absence of the vas deferens, microdeletions within the AZF regions of the Y chromosome, varicocele, cryptorchidism, infections, immunological infertility, and obstructive infertility)
- •- all known aetiologies of female infertility in the partner (tubal blockage, endocrine abnormalities including anovulation and PCO, anatomical abnormalities, infections)
- •- heterozygous FSHR allele at codon 680
- •- drug abuse and major systemic diseases
- •- testicular insufficiency
研究者
相似试验
进行中（未招募）
不适用
Significance of the FSH receptor polymorphism p.N680S for the efficacy of FSH therapy of idiopathic male infertility: a pharmacogenetic approach. - NDIdiopathic male infertilityMedDRA version: 9.1Level: HLGTClassification code 10014701MedDRA version: 9.1Level: LLTClassification code 10021011EUCTR2010-020240-35-ITAZIENDA OSPEDALIERA POLICLINICO DI MODENA100
尚未招募
不适用
FSH receptor polymorphisms and treatment of poor responderspoor response in assisted reproduction techniques (IVF/ICSI)1001470110013356NL-OMON31719Vrije Universiteit Medisch Centrum112
已完成
2 期
FSH Receptor Polymorphism p.N680S and Efficacy of FSH TherapyMale InfertilityNCT02349945Azienda USL Modena88
已完成
不适用
Follicle Stimulating Hormone (FSH) Receptor Polymorphisms in In-Vitro Fertilization Cycles.InfertilityNCT01002885University Reproductive Associates75
招募中
不适用
Genetic variants of sex hormone receptors in patients with atrial fibrillatioI48Atrial fibrillation and flutterDRKS00033526Klinikum Bielefeld Mitte40