Succinylcholine versus Rocuronium for rapid sequence intubation:A randomized open labelled study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To compare the success rate of first-attempt orotracheal intubation in patients
研究概览
简要总结
This is a prospective open labelled randomised control trial of parallel group to compare the success rate of first attempt orotracheal intubation and effects of intravenous Succinylcholine versus Rocuronium in rapid sequence intubation.Patients aged 18 and more are recruited after taking into consideration of inclusion and exclusion criteria with their legally authorised respresentative giving a valid consent, are randomised into two groups- Group S receiving intravenous Succinylcholine as bolus at 1mg/kg and Group-R receiving intravenous Rocuronium as bolus at 1.2 mg/kg. Primary objective is to compare the success rate of first attempt orotracheal intubation in patient receiving Succinylcholine versus Rocuronium, assessed by physician and confirmed by capnography curve consistent over three respiratory cycles.Secondary objective is to evaluate the intuabtion condition by Copenhagen score and percentage of patients intuabted by other techniques along with the complications seen with the use of either drugs in the first 15 minutes post successful orotracheal intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Adults of 18 years and above requiring Rapid sequence Intubation ,their legally authorised representative willing to give a valid consent.
排除标准
- •Legally authorized representative unable or unwilling to give informed consent, Patients less than 18 years of age, Patients with history of cardiac arrest, Patients allergic to succinylcholine or rocuronium Pregnancy, Preexisting myopathies or myasthenia gravis, Preexisting hyperkalemia, Patients with massive edema, immobile jaw from injury or infection, Patients with oropharyngeal tumors.
结局指标
主要结局
To compare the success rate of first-attempt orotracheal intubation in patients
时间窗: To compare the success rate of first-attempt orotracheal intubation in patients | receiving succinylcholine versus rocuronium assessed by the physician and | confirmed by monitoring capnography curve over 12 to 15 seconds (consistent over 3 respiratory cycles) as per ventilator settings of Respiratory rate in a range of 12 to 16 breaths per minutes
receiving succinylcholine versus rocuronium assessed by the physician and
时间窗: To compare the success rate of first-attempt orotracheal intubation in patients | receiving succinylcholine versus rocuronium assessed by the physician and | confirmed by monitoring capnography curve over 12 to 15 seconds (consistent over 3 respiratory cycles) as per ventilator settings of Respiratory rate in a range of 12 to 16 breaths per minutes
confirmed by capnography curve consistent over 3 respiratory cycles.
时间窗: To compare the success rate of first-attempt orotracheal intubation in patients | receiving succinylcholine versus rocuronium assessed by the physician and | confirmed by monitoring capnography curve over 12 to 15 seconds (consistent over 3 respiratory cycles) as per ventilator settings of Respiratory rate in a range of 12 to 16 breaths per minutes
次要结局
- To compare(1.Intubation condition assessed by Copenhagen score)
研究者
Dr Arun K
AIIMS New Delhi