NCT02265003已完成不适用
Red Blood Cells as a Reflection of Endothelial Function in Old Age
Heinrich-Heine University, Duesseldorf1 个研究点 分布在 1 个国家目标入组 140 人开始时间: 2012年7月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- Determination of endothelial function
研究概览
简要总结
The aim of this study is to find out, how far red blood cells reflect age-depended changes in endothelial function.
详细描述
It will be investigated with determination of endothelial function (measured as flow-mediated vasodilation) and of circulated nitric oxid-pool in red blood cells and in blood plasma, how far red blood cells reflect age-depended changes in endothelial function.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy subjects
- •informed consent
排除标准
- •hypertension (blood pressure ≥140/90 mmHg),
- •hypercholesterolemia (LDL ≥250 mg/dl, HDL ≤45 mg/dl),
- •diabetes mellitus (fasting plasma glucose ≥128 mg/dl)
- •acute inflammation (CRP >0.5 mg/dl)
- •malignant diseases
- •heart failure (NYHA III-IV)
- •arrhythmia of high degree
- •acute or terminated kidney disease
- •cardiovascular diseases ( cardiac artery disease, peripheral vascular disease and cerebrovascular diseases)
- •pregnancy
- •Inclusion Criteria:
- •angiographical signs of apparent atherosclerosis (cardiac artery disease or peripheral vascular disease or degenerative valvular heart disease)
- •informed consent
- •Exclusion Criteria:
- •Hypertension (blood pressure ≥140/90 mmHg),
- •Hypercholesterolemia (LDL ≥250 mg/dl, HDL ≤45 mg/dl),
- •Diabetes mellitus (fasting plasma glucose ≥128 mg/dl)
- •acute inflammation (CRP >0.5 mg/dl)
- •malignant diseases
- •heart failure (NYHA III-IV)
- •arrhythmia of high degree
- •acute or terminated kidney disease
- •cardiovascular diseases ( cardiac artery disease, peripheral vascular disease and cerebrovascular diseases)
- •pregnancy
结局指标
主要结局
Determination of endothelial function
时间窗: baseline
measured as flow-mediated vasodilation
次要结局
- Determination of nitric oxide(NO)-pool in red blood cells and blood plasma(baseline)
- Determination of erythrocytes parameter(baseline)
- Cardiovascular Parameter(baseline)
研究者
Klinik für Kardiologie, Pneumologie und Angiologie
Principle Investigator Prof. Dr. Malte Kelm
Heinrich-Heine University, Duesseldorf
研究点 (1)
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