The Impact of Reward-induced Dopamine Release on Functional Connectivity: a Combined PET/fMRI Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- Resting state fMRI
研究概览
简要总结
The present study would be the first to investigate the relationship between reward- and or social stimuli-induced dopamine (DA) release and neural function using a combined PET/fMRI approach. Data from this project conducted in healthy subjects will provide preliminary data for a larger grant application to study patient populations with known abnormalities in DA including schizophrenia, major depressive, substance use, and eating disorders.
详细描述
Aim 1. To test the relationship between reward-induced dopamine (DA) release on changes in resting state functional connectivity (RSFC) in healthy subjects. In 20 healthy adults, the investigators will examine DA release (measured using positron emission tomography, PET) in the ventral striatum, thalamus, and prefrontal cortex, as previously described. Before and after the task the investigators will examine RSFC (measured using functional magnetic resonance imaging, fMRI) between these structures, which have been shown to form functional pathways serving motivation and emotion regulation in rodents and nonhuman primates. The investigators hypothesize that DA release will impact the functional relationship between these and other structures as determined by changes in RSFC.
Aim 2. To examine the relationship between dopamine release and the Reward Positivity (RewP) potential. Subjects will be presented with the option to participate in an event-related potential (ERP) study. The investigators will correlate the amount of DA release with the amplitude of the RewP potential, an ERP that is enhanced in reward versus non-reward circumstances. Based on previous studies, the investigators hypothesize that RewP amplitude will positively correlate with dopamine release in the nucleus accumbens.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women age 18-45 who have the capacity to consent to the protocol.
- •Ability to understand and follow instructions and oriented to name, time, and place.
- •A negative urine pregnancy and toxicology screen
- •Willingness to abstain from using aspirin, NSAIDs, or anticoagulants during the study
排除标准
- •Left-handed or ambidextrous
- •History of seizures
- •History of strokes
- •Clinically significant, uncontrolled liver, kidney, cardiac, or pulmonary disease
- •Terminal medical diagnosis consistent with survival < 1 year
- •Serious mental impairment. Mini mental state exam of < 23/30
- •Current or past DSM-IV Axis I or neurologic disorders
- •Actively abusing substances, including alcohol (regular alcohol use during the past 6 months equal to or greater than 16 cans of beer per week or equivalent; use of street drugs or regular tobacco use during the past 6 months)
- •Unstable medical condition (≥ 3 months), or serious medical illnesses during the past three months (e.g., serious infections)
- •Unexplained loss of consciousness; history of traumatic brain injury involving loss of consciousness greater than 2 minutes
- •Currently pregnant or breastfeeding, sexually active and of child-bearing potential and not using adequate contraceptive methods
- •Childbirth or miscarriage during past 6 months, breastfeeding within 6 months of recruitment
- •Allergic to latex and/or study pharmaceuticals
- •Diabetes and/or unable to fast for up to 7 hours
- •Unable to lie comfortably in the scanner for up to 4 consecutive hours
- •Would receive a total of over 5 rems to a radiosensitive organ (bone marrow, gonads, lens of the eye) or 15 rems to any other organ or to the body as a whole during a 12 month period
- •Contraindications for MRI including neurostimulators, implanted medical devices, metal in the body, claustrophobia, weight over 440 pounds, and girth size incompatible for scanner bore.
- •Participation in a similar Social Feedback Task within 2 months of the start of the study.
结局指标
主要结局
Resting state fMRI
时间窗: 1-3 weeks
Resting state functional connectivity will be measured using fMRI
Event-related potential (ERP) during reward
时间窗: 1-3 weeks
ERP during a reward task is measured
Dopamine receptor binding potential
时间窗: 1-3 weeks
changes in dopamine receptor binding potential will be measured during and after a reward task or social stimulus task
次要结局
未报告次要终点
研究者
David Hsu
Assistant Professor of Psychiatry
Stony Brook University