CHARACTERIZATION OF THE OCULAR SURFACE MICROBIOME IN THE REGION OF EPIRUS AND MACEDONIA (GREECE)
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 45
- 试验地点
- 1
研究概览
简要总结
The effect of latanoprost with preservatives on the ocular surface microbiome
详细描述
Evidence suggests that the ocular surface microbiome of patients using preserved glaucoma eye drops differs from that of healthy individuals. These microbial changes have been linked to both the glaucoma treatment itself and the presence of preservatives, particularly benzalkonium chloride (BAK), in the eye drops. However, existing studies have primarily assessed these differences by comparing treated glaucoma patients to healthy controls, rather than examining changes within the same individuals over time.
The aim of this study is to evaluate how glaucoma medications containing the preservative benzalkonium chloride affect the ocular surface microbiome in the same patients before and after the initiation of therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Newly diagnosed treatment naive glaucoma patients or those with ocular hypertension
排除标准
- •Patients' history of recent ocular surgery or trauma,
- •Patient with any type of conjunctivitis and ocular surface inflammation recent to the time of diagnosis
- •Patients using topical antibiotics
- •Contact lenses wearers
- •Patients in other chronic treatments with eye drops
研究者
Andreas Katsanos
Head, Ophthalmology Department, University Hospital of Ioannina, Greece
University of Ioannina