ISRCTN18501431进行中（未招募）4 期
THRomboprophylaxis in Individuals undergoing superficial endoVEnouos treatment (THRIVE): a multicentre assessor-blind randomized controlled trial
试验速览
- 阶段
- 4 期
- 状态
- 进行中（未招募）
- 入组人数
- 6,660
研究概览
简要总结
2024 Protocol article in https://pubmed.ncbi.nlm.nih.gov/38367965/ (added 19/02/2024)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Adults (>18 years)
- •2. Scheduled to undergo endovenous intervention of truncal varicose veins under local anaesthesia
- •3. Treatment technologies including radiofrequency, laser, mechanochemical, foam sclerotherapy and cyanoacrylate glue
排除标准
- •Current exclusion criteria as of 12/01/2024:
- •1. Clinical indication for therapeutic anticoagulation e.g., atrial fibrillation
- •2. Previous personal or first-degree relative history of VTE
- •3. Thrombophilia
- •4. Female patients of childbearing potential who have a positive pregnancy test
- •5. A history of allergy to heparins or direct oral anticoagulants
- •6. A history of heparin-induced thrombocytopenia
- •7. Inherited and acquired bleeding disorders
- •8. Evidence of active bleeding
- •9. Concomitant major health problems such as active cancer and chronic renal and/or liver impairment
- •10. Known thrombocytopenia (platelets known to be less than 50 x 109/l)
- •11. Surgery or major trauma in the previous 90 days
- •12. Recent ischemic stroke in the previous 90 days
- •13. Inability to provide consent
- •Previous exclusion criteria:
- •1. Clinical indication for therapeutic anticoagulation
- •2. Clinical contraindication to anticoagulation
- •3. Previous personal or family history of VTE
- •4. Thrombophilia
- •5. Inability to provide informed consent or consent by personal/professional legal representative
- •6. A positive test for SARS-CoV2 <3 months of procedure
- •7. Female patients of childbearing age who have a positive pregnancy test
研究者
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