Serum Metabolomics Analysis for Early Diagnosis and Pathogenesis of Gestational Diabetes Mellitus
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 480
- 试验地点
- 1
- 主要终点
- Content of serum metabolomics
研究概览
简要总结
This study aims to collect serum samples from healthy non-pregnant women, pregnant women with and without Gestational Diabetes Mellitus (GDM). We will analyze the metabolite changes among the three groups using clinical metabolomics and identify potential biomarkers and metabolic pathways. This study will provide scientific evidence for early clinical diagnosis, prevention, control, and treatment research of GDM.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •No obvious abnormalities in all inspection items
- •No history of diabetes
- •No particular dietary habits
- •No previous history of other mental illnesses
- •No history of drug abuse or allergies
- •No history of smoking or drinking
排除标准
- •Pregnancy complications such as uterine fibroids, hyperthyroidism/hypothyroidism, and antiphospholipid antibody syndrome
- •Critical illnesses such as cardiovascular disease or abnormal liver/kidney function
- •Personal history of syphilis, HIV positive, and other infectious diseases
- •Artificial insemination or IVF pregnancy
- •Multiple pregnancy (twins or more)
- •Patients participating in other clinical studies
- •Other reasons that researchers think are inappropriate
结局指标
主要结局
Content of serum metabolomics
时间窗: Second trimester (24-28 gestational weeks)
Based on non-targeted metabolomics technology, the metabolites in serum were comprehensively detected. Differential metabolites were screened using multivariate statistical analysis. Then quantitatively detect the content of these metabolites to find the differential metabolites with predictive ability for GDM.
次要结局
未报告次要终点
研究者
Lu LI
Research Professor
Zhejiang University