NCT01308320已完成4 期
Dose-dependent Effect of Fentanyl on Cough Attenuation During Emergence From General Anaesthesia
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 1
研究概览
简要总结
Fentanyl is expected to suppress tracheal tube-induced cough during emergence from general anaesthesia through binding to its receptors in the brainstem. However, it has not been proven if fentanyl has a complication-free, dose-dependent effect on cough suppression during emergence from sevoflurane anaesthesia. The purpose of this study is to evaluate the relationship between fentanyl doses and cough suppression during emergence from sevoflurane anaesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 20 Years 至 59 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •the patients undergoing general anaesthesia for elective thyroidectomy due to thyroid neoplasm.
- •ASA I-II.
- •20-59 years old.
- •female only.
排除标准
- •signs of difficult intubation.
- •risks for perioperative pulmonary aspiration.
- •history of chronic respiratory disease.
- •recent upper respiratory track infection.
- •previous and recent smoking history
研究组 & 干预措施
saline
Placebo Comparator
control group
干预措施: saline (Drug)
F1 group
Active Comparator
F1 group : fentanyl 1 mcg/kg
干预措施: fentanyl citrate (Drug)
F1.5 group
Active Comparator
F1.5 group : fentanyl 1.5 mcg/kg
干预措施: fentanyl citrate (Drug)
F2 group
Active Comparator
F2 group : fentanyl 2 mcg/kg
干预措施: fentanyl citrate (Drug)
研究者
研究点 (1)
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