EUCTR2014-000991-25-GB进行中（未招募）1 期
Pre-surgical metformin for women with endometrial cancer: a randomised placebo controlled trial - Metformin for endometrial cancer RCT
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 90
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
入选标准
- •1. Biopsy-proven type 1 endometrial carcinoma or severe atypical hyperplasia
- •2. Scheduled surgical treatment by hysterectomy n 5-35 days' time
- •3. Informed consent
- •4. Aged 18 years or more
- •Are the trial subjects under 18? no
- •Number of subjects for this age range: 0
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 45
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 45
排除标准
- •1. Current treatment with metformin
- •2. Diabetic on hypoglycaemic medication
- •3. Inability to consent due to lack of capacity or language barriers
- •4. Unable to comply with treatment protocol
- •5. Type 2 endometrial cancer
- •6. Severe renal impairment (Serum creatinine >130umol/L or eGFR <45ml/min/1.732m2)
- •7. Severe hepatic impairment (abnormal LFTs to be discussed on case by case basis with hepatologist)
- •8. Current alcohol abuse
- •9. Sensitivity/hypersensitivity to biguanides
- •10. Current treatment with other mTOR inhibitors or chemotherapeutic agents
研究者
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